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Protein A003137
Author-entered Data
V1.0, Peer Reviewed
Published 30 Aug 2012
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

UCSD Molecule Pages
Published online: 30 Aug 2012 | doi:10.6072/H0.MP.A003137.01


Basis Sequence: Mouse

Gaik Theng Toh1, Hisao Masai1

1Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JP.

Correspondence should be addressed to Hisao Masai:

Cdc7 (Cell division cycle 7), also known as Hsk1 in fission yeast, is an important serine/threonine kinase, whose sequence is conserved from yeasts to mammals. The kinase activity of Cdc7 is regulated during the cell cycle by an activation subunit Dbf4 (also known as Dfp1/Him1 in fission yeast and ASK in mammals,) via heterodimer formation between the two. Cdc7 was first identified in budding yeast as a temperature-sensitive mutant (cdc7ts) defective in cell cycle progression. The budding yeast cdc7ts cells arrest immediately before the onset of S phase at the non-permissive temperature, but resume growth and complete S phase in the absence of ongoing protein synthesis upon return to the permissive temperature. Cdc7 plays a conserved, pivotal role in triggering origin firing through phosphorylation of MCM (mini-chromosome maintenance) proteins. It facilitates the loading of Cdc45 and other replisome factors onto the pre-replicative complex, to generate active replication forks. In addition, it regulates other chromosomal transactions including DNA damage checkpoint, meiotic recombination, bypass DNA synthesis and histone functions. Selective induction of apoptosis in human cancer cells, but not in normal fibroblasts, after Cdc7 inhibition has provoked the effort in the development of Cdc7 inhibitors as potential anti-cancer drugs. Indeed, studies to date have suggested human Cdc7 as a new promising target in cancer therapy.

Alternative names for this molecule: Cdc7; CDC7 cell division cycle 7-like 1 (S. cerevisiae); Cdc7l1; Cell division cycle 71 homolog (S. cerevisiae)-like 1; HsCDC7; Hsk1; huCDC7; muCdc7

Transition Network Graph This molecule exists in 39 states, has 38 transitions between these states and has 19 enzyme functions.

[map] View high resolution network map

Acknowledgments: We thank the members of our laboratory for useful discussion on Cdc7 kinase.