UCSD Molecule Pages
Published online: 19 Apr 2013 | doi:10.6072/H0.MP.A005186.01
Leukocyte surface antigen CD47
Basis Sequence: Human
David R Soto Pantoja1, Sukhbir Kaur2, Thomas W Miller3, Jeffrey S Isenberg4, David D Roberts1
1Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, MD 20892, US. 2Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, MD 20892, US. 3Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Maryland 20892, US. 4Department of Medicine, University of Pittsburgh, PA 15261, US.
Correspondence should be addressed to David D Roberts: firstname.lastname@example.org
CD47, also known as integrin-associated protein (IAP), ovarian cancer antigen OA3, Rh-related antigen and MER6, is a widely expressed transmembrane receptor belonging to the immunoglobulin superfamily. CD47 is the counter-receptor for two members of the signal-regulatory protein (SHPS/SIRP) family and a high-affinity receptor for the secreted protein thrombospondin-1. Interactions with SIRP receptors play roles in self recognition and regulation of innate immune responses. Over-expression of CD47 on some cancers is a negative prognostic factor and protects against innate immune surveillance. Engagement of CD47 on vascular cells by thrombospondin-1 regulates calcium, cAMP, and nitric oxide/cGMP signaling pathways that control blood pressure, tissue perfusion, and angiogenesis. Moreover, CD47 signaling in various cell types regulates pathways that can trigger cell death, limit stem cell self-renewal, regulate mitochondrial homeostasis and other differentiation pathways, and activate protective autophagy responses under tissue stress. On red blood cells CD47 is part of the Rh complex, but on other cell types it associates laterally in the membrane with integrins and specific signaling receptors. Impaired responses to cardiovascular stress and some pathogens in mice lacking CD47 and their enhanced survival of fixed ischemia, ischemia/reperfusion and radiation injuries identify important pathophysiological roles for CD47 in inflammatory responses and adaptation to stress.
Alternative names for this molecule:
Antigen identified by monoclonal antibody 1D8; Antigenic surface determinant protein OA3; CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 glycoprotein; CD47 molecule; IAP; Integrin associated protein; Integrin-associated protein; Integrin-associated signal transducer; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen
This work was supported by the Intramural Research Program of the NIH/NCI (D.D.R.), 1RO1HL108954-01 (NIH/NHLBI), 1P01HL103455-01 (NIH), 11BGIA7210001 (AHA), the Institute for Transfusion Medicine, and the Western Pennsylvania Hemophilia Center (J.S.I.).